Atherosclerosis: Difference between revisions

Some studies have concluded that lipoprotein A is an independent risk factor for coronary artery disease. As lipoprotein A contains apo A, which structurally resembles plasminogen, lipoprotein A interferes with fibrinolysis by competing with plasminogen binding with molecules. This leads to impairment of plasminogen activation, plasmin generation and lysis of fibrin clots. In addition, lipoprotein A binds with macrophages through a high-affinity receptor, promoting foam cell production and deposition of cholesterol in atherosclerotic plaques. As with homocysteine, not all studies support this theory of correlation, although increased risk of cardiovascular events appear to correlate with people with highest lipoprotein A serum level.<br />