Cardiac Arrhythmias: Difference between revisions

Cardiac Arrhythmias (view source)

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 ===Phase 1: Early Rapid Repolarization===
-Immediately following rapid depolarization, the inactivation of the Na<sup>+</sup> channel (I<sub>Na</sub>) and subsequent activation of the outward K<sup>+</sup> channel (I<sub>to</sub>) and the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger produce a early rapid repolarization. Due to the limited role of the Na<sup>+</sup> channel in the upstroke of sinus node and AV node cells and the subsequent slower depolarization, this rapid repolarisation is not visible in their action potentials.
+Immediately following rapid depolarization, the inactivation of the Na<sup>+</sup> channel (I<sub>Na</sub>) and subsequent activation of the outward K<sup>+</sup> channel (I<sub>to</sub>) and the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) produces a early rapid repolarization. Due to the limited role of the Na<sup>+</sup> channel in the upstroke of sinus node and AV node cells and the subsequent slower depolarization, this rapid repolarisation is not visible in their action potentials.
 ===Phase 2: Plateau===