Cardiac Arrhythmias: Difference between revisions

To facilitate diagnoses and treatment of cardiac arrhythmias a basic understanding of the physiological cardiac action potential and cardiac conduction system is required.  

The cardiac action potential is a result of ions flowing through different ion channels. Ion channels are passages for ions (mainly Na⁺, K⁺, Ca²⁺ and Cl^-) that facilitate movement through the cell membrane. Changes in structure of these channels can open, inactivate or close and control current inside and outside the myocytes. Due to different activity and expression of ion channels, the various parts of the cardiac conduction channel have slightly different action potential characteristics. Ion channels are mostly a passive passage, where movement of ions are caused by the electrochemical activity gradient. In addition to these passive ion channels a few ATP-dependent channels exist to fine-tune the action potential. These changes of membrane potential produce and action potential lasting a few hundreds of milliseconds. Disorders is single channels can lead to arrhythmias, as seen in the section [[Primary_Arrhythmias]]. The action potential is conducted throughout the heart by the depolarization of the immediate environment of the cells and through intracellular coupling with gap-junctions. The communication pores are located in cell to cell adhesion structures, the intercalated disks.