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*Captopril | *Captopril | ||
| | | | ||
|Start | |Start 6.25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 6.25mg three times daily. | ||
3-5 weeks | 3-5 weeks 12.5mg three times daily. | ||
>7 weeks | >7 weeks 25mg three times daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Lisinopril | *Lisinopril | ||
| | | | ||
|Start | |Start 2.5-5mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 5-10mg once daily. | ||
5-7 weeks | 5-7 weeks 25mg three times daily. | ||
>7 weeks | >7 weeks 50 mg three times daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Enalapril/quinalapril | *Enalapril/quinalapril | ||
| | | | ||
|Start | |Start 2.5-5mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 2.5-5mg twice daily. | ||
3-5 weeks | 3-5 weeks 5-10mg twice daily. | ||
>7 weeks | >7 weeks 10-20mg twice daily. | ||
|- | |- | ||
|bgcolor="#F0F0F0 " colspan="3"|'''Beta blockers''' | |bgcolor="#F0F0F0 " colspan="3"|'''Beta blockers''' | ||
Line 751: | Line 751: | ||
*Metoprolol zoc (succinate) | *Metoprolol zoc (succinate) | ||
|valign="top"|EF >30-45% and NYHA II-III | |valign="top"|EF >30-45% and NYHA II-III | ||
|Start | |Start 25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 50mg once daily. | ||
3-5 weeks | 3-5 weeks 100mg once daily. | ||
>7 weeks | >7 weeks 100-200mg once daily. | ||
|- | |- | ||
| | | | ||
|valign="top"|EF <30% and NYHA IV | |valign="top"|EF <30% and NYHA IV | ||
|Start | |Start 12.5mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 25mg once daily. | ||
3-5 weeks | 3-5 weeks 50mg once daily. | ||
>7 weeks | >7 weeks 100-200mg once daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Bisoprolol | *Bisoprolol | ||
|valign="top"|EF >30-45% and NYHA II-III | |valign="top"|EF >30-45% and NYHA II-III | ||
|Start | |Start 2.5mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 3.75mg once daily. | ||
3-5 weeks | 3-5 weeks 5mg once daily. | ||
>7 weeks | >7 weeks 7.5-10mg once daily. | ||
|- | |- | ||
| | | | ||
|valign="top"|EF <30% and NYHA IV | |valign="top"|EF <30% and NYHA IV | ||
|Start | |Start 1.25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 2.5mg once daily. | ||
3-5 weeks | 3-5 weeks 3.75mg once daily. | ||
>7 weeks | >7 weeks 5-7.5-10mg once daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Carvedilol | *Carvedilol | ||
|valign="top"|EF >30-45% and NYHA II-III | |valign="top"|EF >30-45% and NYHA II-III | ||
|Start | |Start 6.25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 6.25mg twice daily. | ||
3-5 weeks | 3-5 weeks 12.5mg twice daily. | ||
>7 weeks | >7 weeks 25mg twice daily. | ||
|- | |- | ||
| | | | ||
|valign="top"|EF <30% and NYHA IV | |valign="top"|EF <30% and NYHA IV | ||
|Start | |Start 3.125mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 3.125mg twice daily. | ||
3-5 weeks | 3-5 weeks 6.25mg twice daily. | ||
>7 weeks | >7 weeks 12.5-25mg twice daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Nebivolol | *Nebivolol | ||
|valign="top"|EF >30-45% and NYHA II-III | |valign="top"|EF >30-45% and NYHA II-III | ||
|Start | |Start 1.25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 2.5mg once daily. | ||
3-5 weeks | 3-5 weeks 5mg once daily. | ||
>7 weeks | >7 weeks 10mg once daily. | ||
|- | |- | ||
| | | | ||
|valign="top"|EF <30% and NYHA IV | |valign="top"|EF <30% and NYHA IV | ||
|Start | |Start 1.25mg | ||
1<sup>st</sup> week | 1<sup>st</sup> week 2.5mg once daily. | ||
3-5 weeks | 3-5 weeks 5mg once daily. | ||
>7 weeks | >7 weeks 10mg once daily. | ||
|- | |- | ||
|bgcolor="#F0F0F0 " colspan="3"|'''Aldosterone antagonist''' | |bgcolor="#F0F0F0 " colspan="3"|'''Aldosterone antagonist''' | ||
Line 837: | Line 837: | ||
*Spironolactone/eplerenone | *Spironolactone/eplerenone | ||
| | | | ||
|Start | |Start 25mg s.i.d. | ||
1<sup>st</sup> week | 1<sup>st</sup> week potassium <5.0: 25mg once daily. | ||
potassium 5.0-5.5: 12.5mg once daily. | potassium 5.0-5.5: 12.5mg once daily. | ||
Line 845: | Line 845: | ||
potassium >5.5: stop | potassium >5.5: stop | ||
3rd week | 3rd week potassium <5.0: 25mg once daily. | ||
potassium 5.0-5.5: 12.5mg once daily. | potassium 5.0-5.5: 12.5mg once daily. | ||
Line 854: | Line 854: | ||
*Digoxin | *Digoxin | ||
| | | | ||
|Start | |Start 0.5mg, 0.25mg and 0,25 mg, each with 6 hours in between | ||
Continue with 0.25mg once daily. | Continue with 0.25mg once daily. | ||
Line 865: | Line 865: | ||
*Candesartan | *Candesartan | ||
| | | | ||
|Start | |Start 4mg | ||
3-5 weeks | 3-5 weeks 8mg once daily. | ||
>7 weeks | >7 weeks 16mg once daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*Valsartan | *Valsartan | ||
| | | | ||
|Start | |Start 80mg | ||
3-5 weeks | 3-5 weeks 160mg once daily. | ||
>7 weeks | >7 weeks 320mg once daily. | ||
|- | |- | ||
|colspan="3" bgcolor="#F0F0F0 "|'''Hydralazine and isosorbide dinitrate (H-ISDN)''' | |colspan="3" bgcolor="#F0F0F0 "|'''Hydralazine and isosorbide dinitrate (H-ISDN)''' | ||
Line 885: | Line 885: | ||
*Hydralazine | *Hydralazine | ||
| | | | ||
|Start | |Start 25mg three times daily. | ||
3-5 weeks | 3-5 weeks 50mg three times daily. | ||
>7 weeks | >7 weeks 75-100mg three times daily. | ||
|- | |- | ||
|valign="top"| | |valign="top"| | ||
*ISDN | *ISDN | ||
| | | | ||
|Start | |Start 20mg twice daily | ||
3-5 weeks | 3-5 weeks 40mg twice daily | ||
>7 weeks | >7 weeks 80mg twice daily | ||
|} | |} | ||