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Possible side effects include hyperkalaemia, hyponatremia, worsening renal function, and breast tenderness and/or enlargement. Eplerenon has less mastopathy side effects and is alternative to spironolacton. In patients with severe heart failure, spironolactone in addition to standard therapy, reduces morbidity and mortality <cite>20</cite>. | Possible side effects include hyperkalaemia, hyponatremia, worsening renal function, and breast tenderness and/or enlargement. Eplerenon has less mastopathy side effects and is alternative to spironolacton. In patients with severe heart failure, spironolactone in addition to standard therapy, reduces morbidity and mortality <cite>20</cite>. | ||
[[Image: | [[Image:Henle_loop.svg|thumb|400px|Figure 6 diuretics and site of action in the nephron.]] | ||
===Choice and combination of diuretics=== | ===Choice and combination of diuretics=== |