ICD Primary prevention trials

placeholder

Study	Inclusion Criteria	Number Randomized	Control Group	Primary Point	Main Finding
MADIT I35	Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III	196	Conventional therapy	All-cause mortality	54% RRR in all-cause mortality with ICD (P=0.009); absolute RR 23%
CABG-PATCH36	EF <35%, abnormal SAECG, elective CABG	900	Conventional therapy	All-cause mortality	No difference in all-cause mortality
MUSTT37	Prior MI, EF ≤40%, NSVT, inducible VT on EPS	704	EP-guided antiarrhythmic therapy or conventional therapy	Cardiac arrest or death due to arrhythmia	60% RRR in all-cause mortality with ICD (P=0.001); absolute RR 31%
MADIT II39	Prior MI≤1 month, EF≤30%, NYHA class I–III	1232	Conventional therapy	All-cause mortality	31% RRR in all-cause mortality with ICD (P=0.016); absolute RR 6%
DINAMIT38	Recent (6–40 days) MI, EF≤35%, abnormal HRV or elevated average HR on 24-h Holter, NYHA class I–III	674	Conventional therapy	All-cause mortality	No difference in all-cause mortality; 58% RRR from arrhythmia with ICD (P=0.009)
SCD-HeFT34	EF≤35%, (ischemic or nonischemic) NYHA class II–III	2521	Conventional therapy±amiodarone	All-cause mortality	23% RRR in all-cause mortality with ICD (P=0.007); absolute RR 7%
EF indicates ejection fraction; NSVT, nonsustained VT; EPS, electrophysiological study; NYHA, New York Heart Association; RRR, relative risk reduction; RR, risk reduction; CABG, coronary artery bypass grafting; SAECG, signal-averaged ECG; HRV, heart rate variability; and HR, heart rate.