ICD Primary prevention trials: Difference between revisions

Revision as of 11:41, 15 January 2012

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Study	Inclusion Criteria	Number Randomized	Control Group	Primary Point	Main Finding
MADIT I³⁵	Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III	196	Conventional therapy	All-cause mortality	54% RRR in all-cause mortality with ICD (P=0.009); absolute RR 23%
CABG-PATCH³⁶	EF <35%, abnormal SAECG, elective CABG	900	Conventional therapy	All-cause mortality	No difference in all-cause mortality
MUSTT³⁷	Prior MI, EF ≤40%, NSVT, inducible VT on EPS	704	EP-guided antiarrhythmic therapy or conventional therapy	Cardiac arrest or death due to arrhythmia	60% RRR in all-cause mortality with ICD (P=0.001); absolute RR 31%

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+{| class="wikitable" border="1"
+|-
+! Study
+! Inclusion Criteria
+! Number Randomized
+! Control Group
+! Primary Point
+! Main Finding
+|-
+| MADIT I<sup>35</sup>
+| Prior MI, EF ≤35%, NSVT, inducible and nonsuppressible VT on EPS, NYHA class I–III
+| 196
+| Conventional therapy
+| All-cause mortality
+| 54% RRR in all-cause
+mortality with ICD (''P''=0.009); absolute RR 23%
+|-
+| CABG-PATCH<sup>36</sup>
+| EF <35%, abnormal SAECG, elective CABG
+| 900
+| Conventional therapy
+| All-cause mortality
+| No difference in all-cause mortality
+|-
+| MUSTT<sup>37</sup>
+| Prior MI, EF ≤40%, NSVT, inducible VT on EPS
+| 704
+| EP-guided antiarrhythmic therapy or conventional therapy
+| Cardiac arrest or death due to arrhythmia
+| 60% RRR in all-cause mortality with ICD (''P''=0.001); absolute RR 31%
+|}