401
edits
Heart Failure: Difference between revisions
→Management of HF patients with preserved LVEF (HFPEF)
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{| class="wikitable" border="1" align="left" style="float: center" | {| class="wikitable" border="1" align="left" style="float: center" | ||
|- | |- | ||
| colspan="6" | '''Table 4''' | | colspan="6" style="border-bottom: 0; background-color: white;" | '''Table 4''' | ||
|- | |- | ||
| colspan=" | | colspan="6" align="center" style="border-bottom: 0; border-top: 0; background-color: white;" | '''Size of treatment effect''' | ||
|- | |- | ||
| rowspan="6" | '''Estimate of Certainty (precision) of treatment effect | | rowspan="6" width="100" style="border-right: 0; border-top: 0; background-color: white;" | '''Estimate of Certainty (precision) of treatment effect | ||
| rowspan="2" valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | | | rowspan="2" valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | | ||
| valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class I''' | | valign="top" width="250" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class I''' | ||
Benefit >>> Risk | Benefit >>> Risk | ||
| valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class IIa''' | | valign="top" width="250" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class IIa''' | ||
Benefit >> Risk | Benefit >> Risk | ||
Additional studies with focused objectives needed | Additional studies with focused objectives needed | ||
| valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class IIb''' | | valign="top" width="250" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class IIb''' | ||
Benefit ≥ Risk''' | Benefit ≥ Risk''' | ||
Additional studies with broad objectives needed; additional registry data would be helpful | Additional studies with broad objectives needed; additional registry data would be helpful | ||
| valign="top" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class III''' | | valign="top" width="250" style="border-bottom: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | '''Class III''' | ||
Benefit ≥ Risk | Benefit ≥ Risk | ||
No additional studies needed | No additional studies needed | ||
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| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | Procedure/treatment should not be performed/administered since it is not helpful and may be harmful | | valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: #CCCCFF;" | Procedure/treatment should not be performed/administered since it is not helpful and may be harmful | ||
|- | |- | ||
| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0;" | '''Level A''' | | valign="top" width="200" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: white;" | '''Level A''' | ||
Multiple (3-5) population risk strata evaluated | Multiple (3-5) population risk strata evaluated | ||
| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0;" | - Recommendation that procedure or treatment is useful/effective | | valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation that procedure or treatment is useful/effective | ||
- Sufficient evidence from multiple randomized trials or non-randomized trials | - Sufficient evidence from multiple randomized trials or non-randomized trials | ||
| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0;" | - Recommendation in favor of treatment or procedure being useful/effective | | valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation in favor of treatment or procedure being useful/effective | ||
- Some conflicting evidence from multiple randomized trials or meta-analyses | - Some conflicting evidence from multiple randomized trials or meta-analyses | ||
| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0;" | - Recommendation’s usefulness/efficacy less well established | | valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation’s usefulness/efficacy less well established | ||
- Greater conflicting evidence from multiple randomized trials or meta-analyses | - Greater conflicting evidence from multiple randomized trials or meta-analyses | ||
| valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0;" | - Recommendation that procedure or treatment not useful/effective and may be harmful | | valign="top" style="border-bottom: 0; border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation that procedure or treatment not useful/effective and may be harmful | ||
- Sufficient evidence from multiple randomized trials or meta-analyses | - Sufficient evidence from multiple randomized trials or meta-analyses | ||
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- Limited evidence from single randomized trial or non-randomized studies | - Limited evidence from single randomized trial or non-randomized studies | ||
|- | |- | ||
| valign="top" style="border- | | valign="top" style="border-top: 0; border-left: 0; border-right: 0; background-color: white;" | '''Level C''' | ||
Very limited (1-2) population risk strata evaluated | Very limited (1-2) population risk strata evaluated | ||
| valign="top" style="border- | | valign="top" style="border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation that procedure or treatment is useful/effective | ||
- Only experts opinion, case studies, or standard-of-care | - Only experts opinion, case studies, or standard-of-care | ||
| valign="top" style="border- | | valign="top" style="border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation in favor of treatment or procedure being useful/effective | ||
- Only diverging expert opinion case studies, or standard-of-care | - Only diverging expert opinion case studies, or standard-of-care | ||
| valign="top" style="border- | | valign="top" style="border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation’s usefulness/efficacy less well established | ||
- Only diverging expert opinion case studies, or standard-of-care | - Only diverging expert opinion case studies, or standard-of-care | ||
| valign="top" style="border-top: 0; border-left: 0; border-right: 0;" | - Recommendation that procedure or treatment not useful/effective and may be harmful | | valign="top" style="border-top: 0; border-left: 0; border-right: 0; background-color: white;" | - Recommendation that procedure or treatment not useful/effective and may be harmful | ||
- Only expert opinion case studies, or standard-of-care | - Only expert opinion case studies, or standard-of-care | ||