Cardiac Pharmacology: Difference between revisions

!Dose

|Amount of active drug given to patient

|Drug Specific (From clinical studies)

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!Concentration

|Amount of drug in a given plasma volume

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!EC₅₀

|The concentration of drug needed to elicit a response halfway between zero and maximal responses.

|align="center"|y = bottom + (Top-Bottom)/(1+ [x/EC50] Hill Coefficient)

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!Volume of Distribution

|The theoretical volume the drug would occupy if distributed uniformly throughout the tissues to elicit the current plasma concentration.

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!Elimination Constant (Rate)

|The rate at which the drug is removed from the body.

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!Bioavailability

!Cmax or Cmin

|The maximum (Cmax) /  minimum (Cmin) plasma drug concentration reached following drug administration

|Identified via direct measurement of plasma C

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!tmax

|The time it takes for a drug to reach Cmax following administration

|Identified via direct measurement of plasma C over time

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!Half-life

|The time it takes for a drug to reach half its original concentration

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!Drug Clearance

|The volume of plasma cleared of the drug over a set time

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