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Atherosclerosis: Difference between revisions
→Three pathologic stages of atherogenesis
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== 1.2 Arterial vessel with atherosclerosis == | == 1.2 Arterial vessel with atherosclerosis == | ||
=== Three pathologic stages of atherogenesis === | === Three pathologic stages of atherogenesis === | ||
Atherogenesis can be divided into five key steps, which are 1) endothelial dysfunction, 2) formation of lipid layer or fatty streak within the intima, 3) migration of leukocytes and smooth muscle cells | Atherogenesis can be divided into five key steps, which are 1) endothelial dysfunction, 2) formation of lipid layer or fatty streak within the intima, 3) migration of leukocytes and smooth muscle cells into the vessel wall, 4) foam cell formation and 5) degradation of extracellular matrix. Via these consecutive steps, an atherosclerotic plaque is formed. The formation of the plaque can also be divided into three major stages namely 1) the fatty streak, which represents the initiation 2) plaque progression, which represents adaption and 3) plaque disruption, which represents the clinical complications of atherosclerosis.<br /> | ||
[[File:Figure_7_-_Fatty_streak_formation_revealing_platelet_aggregation_on_the_endothelial_surface.png|right|thumb|Figure 5. Fatty streak formation]] | [[File:Figure_7_-_Fatty_streak_formation_revealing_platelet_aggregation_on_the_endothelial_surface.png|right|thumb|Figure 5. Fatty streak formation]] | ||