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Cardiac Pharmacology: Difference between revisions
→Pharmacokinetics
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|The concentration of drug needed to elicit a response halfway between zero and maximal responses. | |The concentration of drug needed to elicit a response halfway between zero and maximal responses. | ||
|µg/ml (EC<sub>50</sub>) | |µg/ml (EC<sub>50</sub>) | ||
|y=bottom+ | |align="center"|y = bottom + (Top-Bottom)/(1+ [x/EC50] Hill Coefficient) | ||
|- | |- | ||
!Volume of Distribution | !Volume of Distribution | ||
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|How much of the administered dose is available for actual use by the body. | |How much of the administered dose is available for actual use by the body. | ||
|no units as expressing a fraction (f) | |no units as expressing a fraction (f) | ||
|100 × (AUC (po)×D (iv))/(AUC (iv)×D (po)) | |align="center"|100 × (AUC (po)×D (iv))/(AUC (iv)×D (po)) | ||
AUC = Area under curve po = oral administration iv = intravenous administration | AUC = Area under curve po = oral administration iv = intravenous administration | ||